[Optimization for formulation matrix proportion of xiangyu cataplasm by uniform design]

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery Systems
• Pediatric Medicine

Context:

• Infantile diarrhea presents a significant health challenge globally.
• Transdermal drug delivery systems offer a non-invasive alternative for pediatric treatment.
• Optimizing cataplasm formulations is crucial for enhancing therapeutic efficacy and patient compliance.

Purpose:

• To determine the optimal matrix formulation for a cataplasm designed to treat infantile diarrhea.
• To establish a feasible and steerable preparation technique for the cataplasm.
• To validate the safety and effectiveness of the optimized cataplasm as a transdermal drug delivery system.

Summary:

• The optimal matrix formulation for the cataplasm was identified using uniform design and SPSS regression analysis.
• Key formulation components include gelatin, CMC-Na, PANA, kaolin, aluminum trichloride, citric acid, PVP K-30, PEG400, trimethylene glycol, and tween-80 in specific proportions.
• The optimized cataplasm demonstrated favorable adhibition, peeling strength, non-flowing properties, and cream content.

Impact:

• The developed cataplasm represents a safe and effective transdermal drug delivery system for infantile diarrhea.
• The optimized preparation technique ensures feasibility and quality control, paving the way for potential clinical application.
• This research contributes to the advancement of pediatric transdermal therapies, offering a promising treatment option.