Establishment of an International Collaborative Network for N-of-1 Trials and Single-Case Designs

Area of Science:

• Clinical Research Methodology
• Behavioral Science
• Health Services Research

Background:

• Single-Case Designs (SCDs) are crucial for studying individual participant responses in clinical settings.
• The International Collaborative Network for N-of-1 Trials and Single-Case Designs (ICN) was established in 2017 to foster a global community around SCDs.

Purpose of the Study:

• To examine the unique features, history, trends, and clinical applications of SCDs.
• To outline the ICN's key priorities and progress in supporting the SCD scientific community.
• To encourage broader engagement with SCD methodology among researchers, clinicians, and consumers.

Main Methods:

• Review of SCD features, history, and trends.
• Description of the International Collaborative Network for N-of-1 Trials and Single-Case Designs (ICN) activities.
• Summary of a 2019 ICN member survey to identify priorities.

Main Results:

• The ICN has over 420 members across 31 countries.
• Key ICN priorities include developing a communication strategy, resource sharing, incorporating consumer perspectives, writing position papers, and streamlining ethical approvals.
• Progress has been made in network and scientific activities to support SCD research.

Conclusions:

• The ICN provides a platform for collaboration and knowledge exchange in SCDs.
• Encouraging wider adoption of SCDs can lead to improved health outcomes for individuals and populations.
• Membership in the ICN offers a practical way to engage with and advance SCD methodology.