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Biological Sciences

[Toxicological characteristics of ampicillin]

G M Khosid, G B Shteĭnberg, E L Balabanova

Antibiotiki|June 1, 1975

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View abstract on PubMed

Summary

Ampicillin trihydrate exhibits low acute toxicity but can cause allergic reactions and decreased immunity in rats upon inhalation. A maximum permissible concentration of 0.1 mg/m3 is recommended for workplace safety.

Area of Science:

Pharmacology and Toxicology
Immunology

Context:

Occupational exposure to antibiotics in pharmaceutical manufacturing settings.
Assessment of ampicillin trihydrate's toxicological profile.

Purpose:

To evaluate the acute and chronic toxicity of ampicillin trihydrate.
To determine the effects of inhaled ampicillin trihydrate on the immune system.
To establish a safe occupational exposure limit.

Summary:

Ampicillin trihydrate demonstrated low acute toxicity and no cumulative or skin-irritating effects.
Chronic inhalation of ampicillin trihydrate (5 mg/m3) in rats led to immune system compromise and allergic sensitization.
Lower concentrations (0.1 mg/m3) induced immunological reactivity tension, suggesting a need for careful exposure control.

Impact:

Recommends a maximum permissible concentration (MPC) of 0.1 mg/m3 for ampicillin in workplace environments.
Highlights the necessity of an "Allergen" warning label for ampicillin trihydrate.
Provides crucial data for occupational health and safety guidelines in antibiotic production.

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Infectious Agents

[toxicological Characteristics Of Ampicillin]