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A survey of nucleic acid services in core laboratories | JoVE Visualize

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A survey of nucleic acid services in core laboratories

R T Pon¹, G A Buck, R L Niece

¹University Core DNA Services, University of Calgary, AB, Canada.

Biotechniques|September 1, 1994

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Summary

A survey of core facilities reveals substantial DNA synthesis and sequencing output, supporting numerous researchers. These high-throughput core resources offer insights into emerging molecular biology technologies.

Area of Science:

Molecular Biology
Biotechnology
Genomics

Background:

Core facilities provide essential services for DNA synthesis and sequencing.
Understanding the scope and trends of these services is crucial for research advancement.

Purpose of the Study:

To survey core facility services for DNA synthesis and sequencing.
To gather data on instrumentation, volume, users, cost, and methodology.
To assess the role of these facilities as indicators of technological trends.

Main Methods:

Survey distributed by the Association of Biomolecular Resource Facilities.
Responses collected from 85 DNA synthesis facilities and 37 DNA sequencing facilities.
Data collected on various operational and technical criteria.

Main Results:

Combined annual output: 4 million bases (synthesis) and 35 million bases (sequencing).
Facilities support a large number of users.
High sample throughput indicates significant research activity.

Conclusions:

Centralized core facilities perform a substantial volume of DNA synthesis and sequencing.
These facilities are key indicators of current and future technological trends in molecular biology.
The extensive user base highlights the critical role of core resources in supporting scientific research.

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A Survey Of Nucleic Acid Services In Core Laboratories